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Literature summary for 1.1.1.49 extracted from

  • Sung, J.Y.; Lee, Y.N.
    Isoforms of glucose 6-phosphate dehydrogenase in Deinococcus radiophilus (2007), J. Microbiol., 45, 318-325.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ATP 2.0 mM, 65% inhibition, G6PDH-2; G6PDH-1 Deinococcus radiophilus
beta-naphthoquinone-4-sulfonic acid 1 mM, 68% inhibition, G6PDH-1; 1 mM, 81% inhibition, G6PDH-2 Deinococcus radiophilus
Cd2+ 1 mM, 53% inhibition, G6PDH-1 Deinococcus radiophilus
Cu2+ 1 mM, 24% inhibition, G6PDH-1; 1 mM, 78% inhibition, G6PDH-2 Deinococcus radiophilus
EDTA 5 mM, 85% inhibition, G6PDH-1; 5 mM, 97% inhibition, G6PDH-2 Deinococcus radiophilus
Hg2+ 1 mM, 47% inhibition, G6PDH-2; 1 mM, 84% inhibition, G6PDH-1 Deinococcus radiophilus
oleic acid G6PDH-1 is more susceptible to oleic acid than G6PDH-2 Deinococcus radiophilus
Zn2+ 1 mM, 83% inhibition, G6PDH-2; 1 mM, 94% inhibition, G6PDH-1 Deinococcus radiophilus

Metals/Ions

Metals/Ions Comment Organism Structure
Ag+ 1 mM, 1.6fold activation, G6PDH-2 Deinococcus radiophilus
Cd2+ 1 mM, 1.3fold activation, G6PDH-2 Deinococcus radiophilus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35200
-
4 * 35200, G6PDH-1, SDS-PAGE Deinococcus radiophilus
60000
-
2 * 60000, G6PDH-2, SDS-PAGE Deinococcus radiophilus
110000
-
G6PDH-2, gel filtration Deinococcus radiophilus
130000
-
G6PDH-1, gel filtration Deinococcus radiophilus

Organism

Organism UniProt Comment Textmining
Deinococcus radiophilus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
G6PDH-1 Deinococcus radiophilus
G6PDH-2 Deinococcus radiophilus

Source Tissue

Source Tissue Comment Organism Textmining
additional information G6PDH-2 is detected throughout the growth phase Deinococcus radiophilus
-
additional information the enzyme is detected throughout the growth phase. The substantial increase in G6PDH-1 observed at stationary phase or as the results of external oxidative stress indicates that this enzyme is inducible under stressful environmental conditions Deinococcus radiophilus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1033
-
cofactor: NADP+, G6PDH-2 Deinococcus radiophilus
1077
-
cofactor: NAD+, G6PDH-2 Deinococcus radiophilus
2890
-
cofactor: NADP+, G6PDH-1 Deinococcus radiophilus
3078
-
cofactor: NAD+, G6PDH-1 Deinococcus radiophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NAD+
-
Deinococcus radiophilus D-glucono-1,5-lactone 6-phosphate + NADH + H+
-
?
D-glucose 6-phosphate + NADP+
-
Deinococcus radiophilus D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 60000, G6PDH-2, SDS-PAGE Deinococcus radiophilus
tetramer 4 * 35200, G6PDH-1, SDS-PAGE Deinococcus radiophilus

Synonyms

Synonyms Comment Organism
G6PDH-1
-
Deinococcus radiophilus
G6PDH-2
-
Deinococcus radiophilus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
G6PDH-1 Deinococcus radiophilus
30
-
G6PDH-2 Deinococcus radiophilus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
30 min, G6PDH-1 retains 40% of its activity Deinococcus radiophilus
70
-
30 min, G6PDH-2 retains 35% of its activity Deinococcus radiophilus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
G6PDH-1 Deinococcus radiophilus
8
-
G6PDH-2 Deinococcus radiophilus

Cofactor

Cofactor Comment Organism Structure
NAD+ dual coenzyme specificity for NAD+ and NADP+, G6PDH-1 Deinococcus radiophilus
NAD+ dual coenzyme specificity for NAD+ and NADP+, G6PDH-2 Deinococcus radiophilus
NADP+ dual coenzyme specificity for NAD+ and NADP+, G6PDH-1 Deinococcus radiophilus
NADP+ dual coenzyme specificity for NAD+ and NADP+, G6PDH-2 Deinococcus radiophilus

pI Value

Organism Comment pI Value Maximum pI Value
Deinococcus radiophilus isoelectric focusing, pH-range 3-10, G6PDH-2
-
5.7
Deinococcus radiophilus isoelectric focusing, pH-range 3-10, G6PDH-1
-
6.4