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Literature summary for 1.1.1.49 extracted from

  • Oezer, N.; Bilgi, C.; Hamdi Ogus, I.
    Dog liver glucose-6-phosphate dehydrogenase: purification and kinetic properties (2002), Int. J. Biochem. Cell Biol., 34, 253-262.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NADPH has a regulatory role in pentaose phosphate pathway Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics and thermodynamics, rapid equilibrium random bi bi kinetic model Canis lupus familiaris
0.01
-
NADP+ pH 7.4, 37°C, with D-glucose 6-phosphate or 2-deoxy-D-glucose 6-phosphate Canis lupus familiaris
0.122
-
D-glucose 6-phosphate pH 7.4, 37°C, with NADP+ or deamino-NADP+ Canis lupus familiaris
2 3 deamino-NADP+ pH 7.4, 37°C, with D-glucose 6-phosphate Canis lupus familiaris
24
-
2-deoxy-D-glucose 6-phosphate pH 7.4, 37°C, with NADP+ Canis lupus familiaris

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required, can substitute for Mn2+ Canis lupus familiaris
Mn2+ required, can substitute for Mg2+ Canis lupus familiaris
additional information high ionic strength inactivates the enzyme Canis lupus familiaris

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
native PAGE Canis lupus familiaris
52500
-
2 * 52500, SDS-PAGE Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NAD(P)+ Canis lupus familiaris key enzyme catalyzing the first step of the pentose phosphate pathway generating NADPH for anabolic metabolsim pathways and protection systems in the liver D-glucono-1,5-lactone 6-phosphate + NAD(P)H
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2000fold by 2times 2',5'-ADP affinity chromatography and gel filtration Canis lupus familiaris

Reaction

Reaction Comment Organism Reaction ID
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+ rapid equilibrium random bi bi kinetic mechanism Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
130
-
purified enzyme Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-D-glucose 6-phosphate + NADP+
-
Canis lupus familiaris 2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADPH
-
?
D-glucose 6-phosphate + deamino-NADP+
-
Canis lupus familiaris D-glucono-1,5-lactone 6-phosphate + deamino-NADPH
-
?
D-glucose 6-phosphate + NAD(P)+ key enzyme catalyzing the first step of the pentose phosphate pathway generating NADPH for anabolic metabolsim pathways and protection systems in the liver Canis lupus familiaris D-glucono-1,5-lactone 6-phosphate + NAD(P)H
-
?
D-glucose 6-phosphate + NADP+
-
Canis lupus familiaris D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 52500, SDS-PAGE Canis lupus familiaris
More low pH value and low ionic strength cause aggregation of the enzyme in active oligomeric forms, e.g. as tetramer or hexamer Canis lupus familiaris

Synonyms

Synonyms Comment Organism
G6PD
-
Canis lupus familiaris
glucose-6-phosphate dehydrogenase
-
Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Canis lupus familiaris

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
high pH value inactivates the enzyme Canis lupus familiaris

Cofactor

Cofactor Comment Organism Structure
deamino-NADP+ not as effective as NADP+ Canis lupus familiaris
NADP+
-
Canis lupus familiaris

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
NADPH pH 7.4, 37°C Canis lupus familiaris