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Literature summary for 1.1.1.44 extracted from

  • Ruda, G.F.; Campbell, G.; Alibu, V.P.; Barrett, M.P.; Brenk, R.; Gilbert, I.H.
    Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase (2010), Bioorg. Med. Chem., 18, 5056-5062.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
Trypanosoma brucei
2-methyl-5-nitrofuran-3-carboxylic acid
-
Trypanosoma brucei
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
Trypanosoma brucei
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
Trypanosoma brucei
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
Trypanosoma brucei
4-chloro-1H-pyrrole-2-carboxylic acid
-
Trypanosoma brucei
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
Trypanosoma brucei
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
Trypanosoma brucei
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
Trypanosoma brucei
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
Trypanosoma brucei
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Trypanosoma brucei D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
6PGDH
-
Trypanosoma brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0058
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei (2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
0.028
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 2-methyl-5-nitrofuran-3-carboxylic acid
0.042
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
0.042
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 4,5-dichloro-1H-pyrrole-2-carboxylic acid
0.043
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 4-chloro-1H-pyrrole-2-carboxylic acid
0.045
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
0.051
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
0.053
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
0.056
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei [(5-nitrofuran-2-yl)methylidene]propanedioic acid
0.073
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
0.114
-
pH 7.0, temperature not specified in the publication Trypanosoma brucei 3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid