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Literature summary for 1.1.1.44 extracted from

  • Rippa, M.; Giovannini, P.P.; Barrett, M.P.; Dallocchio, F.; Hanau, S.
    6-Phosphogluconate dehydrogenase: The mechanism of action investigated by a comparison of the enzyme from different species (1998), Biochim. Biophys. Acta, 1429, 83-92.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
6-phosphogluconate bona fide allosteric activator Ovis aries

Application

Application Comment Organism
medicine
-
Homo sapiens
medicine 6PGDH might be a target for chemotherapy against parasitic infections as trypanosomiasis Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
6PGDH cDNA encodes a protein with 94% sequence identity with the sheep liver enzyme Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Ovis aries
-
Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
3-Oxo-2-deoxy-6-phosphogluconate competitive inhibitor Trypanosoma brucei
NADPH
-
Homo sapiens
NADPH
-
Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0096
-
2-deoxy-3-oxo-6-phosphogluconate
-
Trypanosoma brucei
0.016
-
6-phosphogluconate
-
Ovis aries
0.023
-
6-phosphogluconate
-
Homo sapiens
0.035
-
6-phosphogluconate
-
Trypanosoma brucei
0.082
-
2-deoxy-3-oxo-6-phosphogluconate
-
Homo sapiens
1.42
-
2-deoxy-3-oxo-6-phosphogluconate
-
Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Homo sapiens
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Ovis aries
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Trypanosoma brucei
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-
Homo sapiens
-
human
-
Ovis aries
-
sheep
-
Trypanosoma brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Ovis aries
purified from an overexpressing Escherichia coli strain Trypanosoma brucei

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
erythrocyte
-
Ovis aries
-
heart
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-3-oxo 6-phosphogluconate + ?
-
Homo sapiens ?
-
?
2-deoxy-3-oxo 6-phosphogluconate + ?
-
Trypanosoma brucei ?
-
?
2-deoxy-3-oxo 6-phosphogluconate + ? no decarboxylation by the liver enzyme Ovis aries ?
-
?
2-deoxy-6-phosphogluconate + NADP+
-
Cyberlindnera jadinii 2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
r
2-deoxy-6-phosphogluconate + NADP+
-
Ovis aries 2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
r
6-phospho-D-gluconate + NADP+
-
Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Trypanosoma brucei D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Subunits

Subunits Comment Organism
dimer
-
Cyberlindnera jadinii
dimer
-
Homo sapiens
dimer
-
Ovis aries
dimer
-
Trypanosoma brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.2 decarboxylation in absence of activators Homo sapiens
6.8 7.2 decarboxylation in absence of activators Trypanosoma brucei
8
-
-
Cyberlindnera jadinii
8
-
6-phosphogluconate oxidation Homo sapiens
8
-
6-phosphogluconate oxidation Ovis aries
8
-
6-phosphogluconate oxidation Trypanosoma brucei
9
-
6-phosphogluconate-activated decarboxylation Trypanosoma brucei
9.1
-
reduction Homo sapiens
9.1
-
reduction Ovis aries
10
-
-
Trypanosoma brucei