Activating Compound | Comment | Organism | Structure |
---|---|---|---|
6-phosphogluconate | bona fide allosteric activator | Ovis aries |
Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
medicine | 6PGDH might be a target for chemotherapy against parasitic infections as trypanosomiasis | Trypanosoma brucei |
Cloned (Comment) | Organism |
---|---|
6PGDH cDNA encodes a protein with 94% sequence identity with the sheep liver enzyme | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Ovis aries |
- |
Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-Oxo-2-deoxy-6-phosphogluconate | competitive inhibitor | Trypanosoma brucei | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0096 | - |
2-deoxy-3-oxo-6-phosphogluconate | - |
Trypanosoma brucei | |
0.016 | - |
6-phosphogluconate | - |
Ovis aries | |
0.023 | - |
6-phosphogluconate | - |
Homo sapiens | |
0.035 | - |
6-phosphogluconate | - |
Trypanosoma brucei | |
0.082 | - |
2-deoxy-3-oxo-6-phosphogluconate | - |
Homo sapiens | |
1.42 | - |
2-deoxy-3-oxo-6-phosphogluconate | - |
Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | Cyberlindnera jadinii | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Homo sapiens | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Ovis aries | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Trypanosoma brucei | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cyberlindnera jadinii | - |
- |
- |
Homo sapiens | - |
human | - |
Ovis aries | - |
sheep | - |
Trypanosoma brucei | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Ovis aries |
purified from an overexpressing Escherichia coli strain | Trypanosoma brucei |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
erythrocyte | - |
Ovis aries | - |
heart | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-3-oxo 6-phosphogluconate + ? | - |
Homo sapiens | ? | - |
? | |
2-deoxy-3-oxo 6-phosphogluconate + ? | - |
Trypanosoma brucei | ? | - |
? | |
2-deoxy-3-oxo 6-phosphogluconate + ? | no decarboxylation by the liver enzyme | Ovis aries | ? | - |
? | |
2-deoxy-6-phosphogluconate + NADP+ | - |
Cyberlindnera jadinii | 2-deoxy-3-oxo 6-phosphogluconate + NADPH | - |
r | |
2-deoxy-6-phosphogluconate + NADP+ | - |
Ovis aries | 2-deoxy-3-oxo 6-phosphogluconate + NADPH | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Cyberlindnera jadinii | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Trypanosoma brucei | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Cyberlindnera jadinii |
dimer | - |
Homo sapiens |
dimer | - |
Ovis aries |
dimer | - |
Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | 7.2 | decarboxylation in absence of activators | Homo sapiens |
6.8 | 7.2 | decarboxylation in absence of activators | Trypanosoma brucei |
8 | - |
- |
Cyberlindnera jadinii |
8 | - |
6-phosphogluconate oxidation | Homo sapiens |
8 | - |
6-phosphogluconate oxidation | Ovis aries |
8 | - |
6-phosphogluconate oxidation | Trypanosoma brucei |
9 | - |
6-phosphogluconate-activated decarboxylation | Trypanosoma brucei |
9.1 | - |
reduction | Homo sapiens |
9.1 | - |
reduction | Ovis aries |
10 | - |
- |
Trypanosoma brucei |