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Literature summary for 1.1.1.44 extracted from
- NADPH activates a decarboxylation reaction catalyzed by lamb liver 6-phosphogluconate dehydrogenase (1992), Biochim. Biophys. Acta, 1122, 273-277.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.043 | - |
6-phosphogluconate | - |
Ovis aries |  |
| 1.42 | - |
2-deoxy-6-phosphogluconate | - |
Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NADP+ | Cyberlindnera jadinii | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | Homo sapiens | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | Ovis aries | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cyberlindnera jadinii | - |
- |
- |
| Homo sapiens | - |
human | - |
| Ovis aries | - |
lamb | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Ovis aries | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Ovis aries | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.33 | - |
- |
Ovis aries |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-deoxy-6-phosphogluconate + NADP+ | - |
Cyberlindnera jadinii | 2-deoxy-3-oxo 6-phosphogluconate + NADPH | - |
r | |
| 2-deoxy-6-phosphogluconate + NADP+ | - |
Ovis aries | 2-deoxy-3-oxo 6-phosphogluconate + NADPH | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Cyberlindnera jadinii | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Cyberlindnera jadinii |
| dimer | - |
Homo sapiens |
| dimer | - |
Ovis aries |
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Release 2023.1 (January 2023)
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