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Literature summary for 1.1.1.42 extracted from

  • Park, S.Y.; Lee, S.M.; Shin, S.W.; Park, J.W.
    Inactivation of mitochondrial NADP+-dependent isocitrate dehydrogenase by hypochlorous acid (2008), Free Radic. Res., 42, 467-473.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
HOCl i.e. hypochlorous acid, the HOCl-mediated damage to NADP+-dependent isocitrate dehydrogenase mayesult in perturbation of the cellular antioxidant defense mechanism and subsequently lead to a pro-oxidant condition Homo sapiens
HOCl i.e. hypochlorous acid Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P48735
-
-
Mus musculus O88844
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + CO2 + NADPH + H+
-
?
isocitrate + NADP+
-
Mus musculus 2-oxoglutarate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
IDPm
-
Homo sapiens
IDPm
-
Mus musculus
NADP+-dependent isocitrate dehydrogenase
-
Homo sapiens
NADP+-dependent isocitrate dehydrogenase
-
Mus musculus