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Literature summary for 1.1.1.41 extracted from

  • Yang, F.; Zhang, S.; Zhou, Y.J.; Zhu, Z.; Lin, X.; Zhao, Z.K.
    Characterization of the mitochondrial NAD+-dependent isocitrate dehydrogenase of the oleaginous yeast Rhodosporidium toruloides (2012), Appl. Microbiol. Biotechnol., 94, 1095-1105.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene RtIDH1, DNA and amino acid sequence determination and analysis, sequence comparison, expression in the Saccharomyces cerevisiae strain BY4741 idhDELTA mutant, RtIdh expression leads to increased intracellular lipid content and extracellular citrate concentration with increasing carbon/nitrogen molar ratio of the media under nitrogen limiting conditions Rhodotorula toruloides
gene RtIDH2, DNA and amino acid sequence determination and analysis, sequence comparison, expression in the Saccharomyces cerevisiae strain BY4741 idhDELTA mutant, RtIdh expression leads to increased intracellular lipid content and extracellular citrate concentration with increasing carbon/nitrogen molar ratio of the media under nitrogen limiting conditions Rhodotorula toruloides

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rhodotorula toruloides 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Rhodotorula toruloides
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Rhodotorula toruloides AS 2.1389
-
2-oxoglutarate + CO2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rhodotorula toruloides G1APK2 gene RtIDH1; gene RtIDH1
-
Rhodotorula toruloides G1APK3 gene RtIDH2; gene RtIDH2
-
Rhodotorula toruloides AS 2.1389 G1APK2 gene RtIDH1; gene RtIDH1
-
Rhodotorula toruloides AS 2.1389 G1APK3 gene RtIDH2; gene RtIDH2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Rhodotorula toruloides 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Rhodotorula toruloides AS 2.1389 2-oxoglutarate + CO2 + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
IDH
-
Rhodotorula toruloides
NAD+-dependent isocitrate dehydrogenase
-
Rhodotorula toruloides
NAD+-specific IDH
-
Rhodotorula toruloides

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Rhodotorula toruloides

General Information

General Information Comment Organism
metabolism regulatory controls of key enzymes during microbial lipid accumulation involving the enzyme, overview Rhodotorula toruloides