Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.41 extracted from

  • Anderson, S.L.; Schirf, V.; McAlister-Henn, L.
    Effect of AMP on mRNA binding by yeast NAD+-specific isocitrate dehydrogenase (2002), Biochemistry, 41, 7065-7073.
    View publication on PubMed
Search for more literature for 1.1.1.41

Activating Compound

Activating Compound Comment Organism Structure
AMP activation of the enzyme and reduction of enzyme inhibition by mitochondrial mRNA, highly enhanced by presence of isocitrate, complex formation, overview Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
mRNA enzyme specifically binds to 5'-untranslated regions of yeast mitochondrial mRNAs, and transcripts containing these regions allosterically inhibit the enzyme, which can be relieved by activator AMP in presence of isocitrate, complex formation, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Saccharomyces cerevisiae enzyme has a regulatory role in the tricarboxylic cycle 2-oxoglutarate + CO2 + NADH + H+
-
 ?
additional information Saccharomyces cerevisiae allosteric regulation, enzyme specifically binds to 5'-untranslated regions of yeast mitochondrial mRNAs, and transcripts containing these regions allosterically inhibit the enzyme, which can be relieved by activator AMP in presence of isocitrate, complex formation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
 Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH + H+
-
 ?
isocitrate + NAD+ enzyme has a regulatory role in the tricarboxylic cycle Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH + H+
-
 ?
additional information allosteric regulation, enzyme specifically binds to 5'-untranslated regions of yeast mitochondrial mRNAs, and transcripts containing these regions allosterically inhibit the enzyme, which can be relieved by activator AMP in presence of isocitrate, complex formation, overview Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
IDH
-
 Saccharomyces cerevisiae
NAD+-specific isocitrate dehydrogenase
-
 Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Saccharomyces cerevisiae