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Literature summary for 1.1.1.40 extracted from

  • Kim, G.H.; Lee, Y.E.; Lee, G.H.; Cho, Y.H.; Lee, Y.N.; Jang, Y.; Paik, D.; Park, J.J.
    Overexpression of malic enzyme in the larval stage extends Drosophila lifespan (2015), Biochem. Biophys. Res. Commun., 456, 676-682.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Drosophila melanogaster 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NADP+ Drosophila melanogaster
-
pyruvate + CO2 + NADPH
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
Drosophila melanogaster pyruvate + CO2 + NADPH
-
?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Drosophila melanogaster

General Information

General Information Comment Organism
physiological function malic enzyme overexpression during the larval period lengthenes the lifespan of Drosophila melanogaster. Metabolic changes mediated by the enzyme during development are related to the control of reactive oxygen species tolerance and the longevity of Drosophila Drosophila melanogaster