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Literature summary for 1.1.1.40 extracted from

  • Guay, C.; Madiraju, S.R.; Aumais, A.; Joly, E.; Prentki, M.
    A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion (2007), J. Biol. Chem., 282, 35657-35665.
    View publication on PubMed
Search for more literature for 1.1.1.40

Protein Variants

Protein Variants Comment Organism
moe enzyme inactivation by shRNA, ME1 activity is reduced by 62% and glucose-induced insulin secretion is decreased Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NADP+ Rattus norvegicus the enzyme is involved in glucose-induced insulin secretion, overview pyruvate + CO2 + NADPH
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 832/13 cell
-
 Rattus norvegicus
-
pancreatic beta cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
 Rattus norvegicus pyruvate + CO2 + NADPH
-
 r
(S)-malate + NADP+ the enzyme is involved in glucose-induced insulin secretion, overview Rattus norvegicus pyruvate + CO2 + NADPH
-
 r

Synonyms

Synonyms Comment Organism
cytosolic malic enzyme
-
 Rattus norvegicus
malic enzyme
-
 Rattus norvegicus
ME1
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus