Literature summary for 1.1.1.40 extracted from

Chang, G.G.; Huang, T.M.; Wang, J.K.; Lee, H.J.; Chou, W.Y.; Meng, C.L.
Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line (1992), Arch. Biochem. Biophys., 296, 468-473.

Search for more literature for 1.1.1.40

Inhibitors

Inhibitors	Comment	Organism	Structure
(NH4)2SO4	at high concentrations	Homo sapiens
ATP	non-competitive versus L-malate	Homo sapiens
NaCl	at high concentrations	Homo sapiens
Tartronate	noncompetitive inhibitor with respect to L-malate	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+	sequential ordered bi-ter kinetic mechanism with NADP+ as the leading substrate followed by L-malate. The products are released in the order of CO2, pyruvate and NADPH	Homo sapiens	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell line	breast cancer cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-malate + NADP+	-	Homo sapiens	pyruvate + CO2 + NADPH	-	?

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
30	-	completely stable for at least 20 min	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Homo sapiens

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Release 2023.1 (January 2023)