KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0031 | - |
NADP+ | - |
Homo sapiens | |
7.2 | - |
pyruvate | - |
Homo sapiens | |
23 | - |
CO2 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
64000 | - |
4 * 64000, SDS-PAGE | Homo sapiens |
257000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
90.9 | - |
mitochondrial enzyme | Homo sapiens |
91.4 | - |
cytosolic enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NAD+ | lower activity than with NADP+ | Homo sapiens | pyruvate + CO2 + NADH | - |
? | |
(S)-malate + NADP+ | - |
Homo sapiens | pyruvate + CO2 + NADPH | - |
r | |
Oxaloacetate | - |
Homo sapiens | Pyruvate + CO2 | - |
? | |
pyruvate + CO2 + NADPH | - |
Homo sapiens | L-malate + NADP+ | - |
r | |
pyruvate + CO2 + NADPH | - |
Homo sapiens | (S)-malate + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 64000, SDS-PAGE | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
cytosolic enzyme, NADPH-dependent reductive carboxylation of pyruvate | Homo sapiens |
8 | - |
NADP+-dependent decarboxylation of malate, at 10 mM malate, mitochondrial enzyme and cytosolic enzyme | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.8 | 8 | pH 6.8: about 40% of maximal activity, pH 8.0: about 70% of maximal activity, cytosolic enzyme, NADPH-dependent reductive carboxylation of pyruvate | Homo sapiens |
7.1 | 8.6 | pH 7.1: about 65% of maximal activity, pH 8.6: about 75% of maximal activity, NADP+-dependent decarboxylation of malate, at 10 mM malate, mitochondrial enzyme and cytosolic enzyme | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | cofactor | Homo sapiens | |
NADPH | cofactor | Homo sapiens |