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Literature summary for 1.1.1.40 extracted from

  • Lin, R.C.; Davis, E.J.
    Malic enzymes of rabbit heart mitochondria. Separation and comparison of some characteristics of a nicotinamide adenine dinucleotide-preferring and a nicotinamide adenine dinuclweotide phosphate-specific enzyme (1974), J. Biol. Chem., 249, 3867-3875.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
oxalate
-
Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
NADP+ activation by Mn2+ Oryctolagus cuniculus
0.025
-
NADP+ activation by Mg2+ Oryctolagus cuniculus
1.06
-
(S)-malate activation by Mn2+ Oryctolagus cuniculus
1.06
-
(S)-malate in the presence of 10 mM Mn2+, at pH 7.4 and 25°C Oryctolagus cuniculus
3.63
-
(S)-malate activation by Mg2+ Oryctolagus cuniculus
3.63
-
(S)-malate in the presence of 10 mM Mg2+, at pH 7.4 and 25°C Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Oryctolagus cuniculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requires low concentration of Mn2+ or Mg2+ for activity, Km: 0.24 mM Oryctolagus cuniculus
Mn2+ Km: 0.01 mM Oryctolagus cuniculus
Mn2+ requires low concentration of Mn2+ or Mg2+ for activity Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
180000
-
gel filtration Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
Oryctolagus cuniculus pyruvate + CO2 + NADPH
-
r
Oxaloacetate
-
Oryctolagus cuniculus Pyruvate + CO2
-
?
pyruvate + CO2 + NADPH 6% of the activity of the NADP+-linked oxidative decarboxylation of malate Oryctolagus cuniculus L-malate + NADP+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Oryctolagus cuniculus