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Literature summary for 1.1.1.4 extracted from

  • Ji, X.J.; Huang, H.; Li, S.; Du, J.; Lian, M.
    Enhanced 2,3-butanediol production by altering the mixed acid fermentation pathway in Klebsiella oxytoca (2008), Biotechnol. Lett., 30, 731-734.
    View publication on PubMed
Search for more literature for 1.1.1.4

Application

Application Comment Organism
synthesis the enzyme is useful in production of 2,3-butanediol, an important starting material for the manufacture of bulk chemicals such as methyl ethyl ketone and 1,3-butadiene Klebsiella oxytoca

Protein Variants

Protein Variants Comment Organism
additional information mutagenesis of wild-type strain ME-303 enzyme induced by UV-light coupled with diethyl sulfate and a modified proton suicide method leading to 7.8% increased butane-2,3-diol production, and a decrease in the corresponding byproducts of lactic and acetic acid by 88% and 92%, respectively, overview Klebsiella oxytoca

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R,R)-butane-2,3-diol + NAD+ Klebsiella oxytoca
-
 (R)-acetoin + NADH + H+
-
 r
(R,R)-butane-2,3-diol + NAD+ Klebsiella oxytoca ME-303
-
 (R)-acetoin + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Klebsiella oxytoca
-
-
-
Klebsiella oxytoca ME-303
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R,R)-butane-2,3-diol + NAD+
-
 Klebsiella oxytoca (R)-acetoin + NADH + H+
-
 r
(R,R)-butane-2,3-diol + NAD+
-
 Klebsiella oxytoca ME-303 (R)-acetoin + NADH + H+
-
 r