Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gossypol | IC50: 0.0115 mM | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
acetylpyridine adenine dinucleotide | pH 7.5 | Plasmodium falciparum | |
0.03 | - |
oxaloacetate | pH 7.5 | Plasmodium falciparum | |
0.036 | - |
NADH | pH 7.5 | Plasmodium falciparum | |
0.152 | - |
NAD+ | pH 10.2 | Plasmodium falciparum | |
0.37 | - |
reduced acetylpyridine adenine dinucleotide | pH 10.2 | Plasmodium falciparum | |
1.35 | - |
malate | pH 10.2 | Plasmodium falciparum | |
5.44 | - |
alpha-ketomalonate | pH 7.5 | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q6VVP7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
schizont | high protein level | Plasmodium falciparum | - |
trophozoite | highest level of transcript, high protein level | Plasmodium falciparum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + acetylpyridine adenine dinucleotide | - |
Plasmodium falciparum | oxaloacetate + reduced acetylpyridine adenine dinucleotide | - |
? | |
(S)-malate + NAD+ | - |
Plasmodium falciparum | oxaloacetate + NADH + H+ | - |
r | |
alpha-ketomalonate + NADH | - |
Plasmodium falciparum | ? | - |
? | |
malate + NAD+ | - |
Plasmodium falciparum | oxaloacetate + NADH + H+ | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
150 | - |
NAD+ | pH 10.2 | Plasmodium falciparum | |
175 | - |
reduced acetylpyridine adenine dinucleotide | pH 10.2 | Plasmodium falciparum | |
250 | - |
malate | pH 10.2 | Plasmodium falciparum | |
674 | - |
alpha-ketomalonate | pH 7.5 | Plasmodium falciparum | |
950 | - |
NADH | pH 7.5 | Plasmodium falciparum | |
960 | - |
oxaloacetate | pH 7.5 | Plasmodium falciparum | |
1010 | - |
acetylpyridine adenine dinucleotide | pH 7.5 | Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | cannot use NADP+ and NADPH as cofactor | Plasmodium falciparum | |
NAD+ | - |
Plasmodium falciparum | |
NADH | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0115 | - |
IC50: 0.0115 mM | Plasmodium falciparum | gossypol |