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Literature summary for 1.1.1.37 extracted from

  • Tripathi, A.K.; Desai, P.V.; Pradhan, A.; Khan, S.I.; Avery, M.A.; Walker, L.A.; Tekwani, B.L.
    An a-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum: Cloning and biochemical characterization of the enzyme (2004), Eur. J. Biochem., 271, 3488-3502.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
gossypol IC50: 0.0115 mM Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
acetylpyridine adenine dinucleotide pH 7.5 Plasmodium falciparum
0.03
-
oxaloacetate pH 7.5 Plasmodium falciparum
0.036
-
NADH pH 7.5 Plasmodium falciparum
0.152
-
NAD+ pH 10.2 Plasmodium falciparum
0.37
-
reduced acetylpyridine adenine dinucleotide pH 10.2 Plasmodium falciparum
1.35
-
malate pH 10.2 Plasmodium falciparum
5.44
-
alpha-ketomalonate pH 7.5 Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q6VVP7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
schizont high protein level Plasmodium falciparum
-
trophozoite highest level of transcript, high protein level Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + acetylpyridine adenine dinucleotide
-
Plasmodium falciparum oxaloacetate + reduced acetylpyridine adenine dinucleotide
-
?
(S)-malate + NAD+
-
Plasmodium falciparum oxaloacetate + NADH + H+
-
r
alpha-ketomalonate + NADH
-
Plasmodium falciparum ?
-
?
malate + NAD+
-
Plasmodium falciparum oxaloacetate + NADH + H+
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
150
-
NAD+ pH 10.2 Plasmodium falciparum
175
-
reduced acetylpyridine adenine dinucleotide pH 10.2 Plasmodium falciparum
250
-
malate pH 10.2 Plasmodium falciparum
674
-
alpha-ketomalonate pH 7.5 Plasmodium falciparum
950
-
NADH pH 7.5 Plasmodium falciparum
960
-
oxaloacetate pH 7.5 Plasmodium falciparum
1010
-
acetylpyridine adenine dinucleotide pH 7.5 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
additional information cannot use NADP+ and NADPH as cofactor Plasmodium falciparum
NAD+
-
Plasmodium falciparum
NADH
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0115
-
IC50: 0.0115 mM Plasmodium falciparum gossypol