Protein Variants | Comment | Organism |
---|---|---|
D374Q | kcat/Km for D-glucose 6-phosphate is 7.7fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 7.3fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 12.2fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
K182Q | kcat/Km for D-glucose 6-phosphate is 127fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1.1fold higher compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.4fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
K182R | kcat/Km for D-glucose 6-phosphate is 81fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1.1fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.6fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
K343Q | kcat/Km for D-glucose 6-phosphate is 445fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 2.7fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 2.6fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
K343R | kcat/Km for D-glucose 6-phosphate is 23fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1.2fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 2fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
P149G | kcat/Km for D-glucose 6-phosphate is 890fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 120fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 448fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
P149V | kcat/Km for D-glucose 6-phosphate is 5933fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1265fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 3843fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
Q47A | kcat/Km for D-glucose 6-phosphate is 1.1fold higher compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1.3fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.8fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
Q47E | kcat/Km for D-glucose 6-phosphate is 1.3fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 6.4fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.7fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
R46E | kcat/Km for D-glucose 6-phosphate is 4.8fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1406fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 6.7fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
T14A | kcat/Km for D-glucose 6-phosphate is 1.8fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 5.7fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 12.8fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
T14S | kcat/Km for D-glucose 6-phosphate is 1.1fold higher compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1.6fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.5fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
Y179F | kcat/Km for D-glucose 6-phosphate is 4.9fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 2.2fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.7fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
Y415F | kcat/Km for D-glucose 6-phosphate is 1.2fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NADP+ is 1.4fold lower compared to kcat/KM of wild-type enzyme, kcat/Km for NAD+ is 1.6fold lower compared to kcat/KM of wild-type enzyme | Leuconostoc mesenteroides |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Leuconostoc mesenteroides |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0065 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides | |
0.0075 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47A | Leuconostoc mesenteroides | |
0.008 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
0.013 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
0.014 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
0.014 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
0.015 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides | |
0.018 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
0.024 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
0.046 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343Q | Leuconostoc mesenteroides | |
0.063 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y415F | Leuconostoc mesenteroides | |
0.063 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
0.074 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y415F | Leuconostoc mesenteroides | |
0.075 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14S | Leuconostoc mesenteroides | |
0.075 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47A | Leuconostoc mesenteroides | |
0.082 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides | |
0.084 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
0.086 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides | |
0.096 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47A | Leuconostoc mesenteroides | |
0.116 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
0.118 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14S | Leuconostoc mesenteroides | |
0.132 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme R46E | Leuconostoc mesenteroides | |
0.135 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme D374Q | Leuconostoc mesenteroides | |
0.165 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y179F | Leuconostoc mesenteroides | |
0.169 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14A | Leuconostoc mesenteroides | |
0.184 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
0.193 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme D374Q | Leuconostoc mesenteroides | |
0.199 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
0.233 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47E | Leuconostoc mesenteroides | |
0.234 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Q47A | Leuconostoc mesenteroides | |
0.239 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47E | Leuconostoc mesenteroides | |
0.31 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
0.338 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
0.378 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14A | Leuconostoc mesenteroides | |
0.379 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides | |
0.441 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y179F | Leuconostoc mesenteroides | |
0.503 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K343Q | Leuconostoc mesenteroides | |
0.571 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
0.825 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149G | Leuconostoc mesenteroides | |
0.986 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme R46E | Leuconostoc mesenteroides | |
1.04 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme R46E | Leuconostoc mesenteroides | |
1.08 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149V | Leuconostoc mesenteroides | |
1.3 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343R | Leuconostoc mesenteroides | |
1.73 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149V | Leuconostoc mesenteroides | |
1.76 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
2.23 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
2.3 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides | |
2.6 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149G | Leuconostoc mesenteroides | |
3.08 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343R | Leuconostoc mesenteroides | |
3.7 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182R | Leuconostoc mesenteroides | |
6.8 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182Q | Leuconostoc mesenteroides | |
13.1 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182Q | Leuconostoc mesenteroides | |
16.1 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182R | Leuconostoc mesenteroides | |
21 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme R46E | Leuconostoc mesenteroides | |
25.3 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343Q | Leuconostoc mesenteroides | |
106 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343Q | Leuconostoc mesenteroides |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NAD+ | Leuconostoc mesenteroides | - |
6-phospho-D-glucono-1,5-lactone + NADH + H+ | - |
? | |
D-glucose 6-phosphate + NADP+ | Leuconostoc mesenteroides | - |
6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leuconostoc mesenteroides | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NAD+ | - |
Leuconostoc mesenteroides | 6-phospho-D-glucono-1,5-lactone + NADH + H+ | - |
? | |
D-glucose 6-phosphate + NADP+ | - |
Leuconostoc mesenteroides | 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Leuconostoc mesenteroides |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.6 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149V | Leuconostoc mesenteroides | |
0.6 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
2.7 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149V | Leuconostoc mesenteroides | |
2.7 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
8.5 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149G | Leuconostoc mesenteroides | |
8.5 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
17.5 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149G | Leuconostoc mesenteroides | |
17.5 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
75.2 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme D374Q | Leuconostoc mesenteroides | |
75.2 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
183 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y415F | Leuconostoc mesenteroides | |
183 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
208 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme D374Q | Leuconostoc mesenteroides | |
208 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
235 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47A | Leuconostoc mesenteroides | |
235 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47A | Leuconostoc mesenteroides | |
255 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182Q | Leuconostoc mesenteroides | |
255 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides | |
263 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y179F | Leuconostoc mesenteroides | |
263 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
308 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182Q | Leuconostoc mesenteroides | |
308 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides | |
317 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y415F | Leuconostoc mesenteroides | |
317 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
378 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14S | Leuconostoc mesenteroides | |
378 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
403 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343R | Leuconostoc mesenteroides | |
403 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
475 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y179F | Leuconostoc mesenteroides | |
475 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
552 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47E | Leuconostoc mesenteroides | |
552 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
577 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47A | Leuconostoc mesenteroides | |
577 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Q47A | Leuconostoc mesenteroides | |
583 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14S | Leuconostoc mesenteroides | |
583 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
585 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182R | Leuconostoc mesenteroides | |
585 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides | |
632 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14A | Leuconostoc mesenteroides | |
632 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides | |
633 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme R46E | Leuconostoc mesenteroides | |
633 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme R46E | Leuconostoc mesenteroides | |
658 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme R46E | Leuconostoc mesenteroides | |
658 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme R46E | Leuconostoc mesenteroides | |
712 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343Q | Leuconostoc mesenteroides | |
712 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343Q | Leuconostoc mesenteroides | |
750 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343R | Leuconostoc mesenteroides | |
750 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
808 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47E | Leuconostoc mesenteroides | |
808 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14A | Leuconostoc mesenteroides | |
808 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
808 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides | |
850 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343Q | Leuconostoc mesenteroides | |
850 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K343Q | Leuconostoc mesenteroides | |
1068 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182R | Leuconostoc mesenteroides | |
1068 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Leuconostoc mesenteroides |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0067 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
0.0073 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
0.0078 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides | |
0.0079 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
0.008 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides | |
0.016 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
0.017 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
0.019 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
0.034 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
0.087 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
0.169 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149V | Leuconostoc mesenteroides | |
1.2 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
1.7 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149V | Leuconostoc mesenteroides | |
3.34 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149G | Leuconostoc mesenteroides | |
6.7 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343Q | Leuconostoc mesenteroides | |
8.9 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y415F | Leuconostoc mesenteroides | |
10.2 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
21.7 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149G | Leuconostoc mesenteroides | |
23.4 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182Q | Leuconostoc mesenteroides | |
30 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme R46E | Leuconostoc mesenteroides | |
33.4 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343Q | Leuconostoc mesenteroides | |
33.4 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149V | Leuconostoc mesenteroides | |
36.7 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182R | Leuconostoc mesenteroides | |
132 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343R | Leuconostoc mesenteroides | |
284 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182R | Leuconostoc mesenteroides | |
351 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme P149G | Leuconostoc mesenteroides | |
351 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides | |
367 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
384 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme D374Q | Leuconostoc mesenteroides | |
601 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343R | Leuconostoc mesenteroides | |
601 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y179F | Leuconostoc mesenteroides | |
618 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme R46E | Leuconostoc mesenteroides | |
668 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme R46E | Leuconostoc mesenteroides | |
1553 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme D374Q | Leuconostoc mesenteroides | |
1670 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14A | Leuconostoc mesenteroides | |
1687 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K343Q | Leuconostoc mesenteroides | |
2221 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
2304 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47E | Leuconostoc mesenteroides | |
2472 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Q47A | Leuconostoc mesenteroides | |
2589 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
2605 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
2739 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
2822 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides | |
2889 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y179F | Leuconostoc mesenteroides | |
2939 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
3123 | - |
NAD+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides | |
3140 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47A | Leuconostoc mesenteroides | |
3206 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14S | Leuconostoc mesenteroides | |
3474 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47E | Leuconostoc mesenteroides | |
3814 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182Q | Leuconostoc mesenteroides | |
4760 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14A | Leuconostoc mesenteroides | |
4993 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme R46E | Leuconostoc mesenteroides | |
5043 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y415F | Leuconostoc mesenteroides | |
5778 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme D374Q | Leuconostoc mesenteroides | |
6012 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47A | Leuconostoc mesenteroides | |
6579 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47E | Leuconostoc mesenteroides | |
7364 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14A | Leuconostoc mesenteroides | |
7799 | - |
D-glucose 6-phosphate | 25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14S | Leuconostoc mesenteroides | |
15500 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343Q | Leuconostoc mesenteroides | |
18870 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y179F | Leuconostoc mesenteroides | |
27050 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme T14S | Leuconostoc mesenteroides | |
29230 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Y415F | Leuconostoc mesenteroides | |
31400 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme Q47A | Leuconostoc mesenteroides | |
33900 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K343R | Leuconostoc mesenteroides | |
39080 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182R | Leuconostoc mesenteroides | |
46760 | - |
NADP+ | 25°C, pH 7.8, mutant enzyme K182Q | Leuconostoc mesenteroides |