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Literature summary for 1.1.1.354 extracted from

  • Bhandari, J.; Fitzpatrick, A.H.; Crowell, D.N.
    Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis thaliana (2010), Plant Physiol., 154, 1116-1127.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of recombinant Arabidopsis farnesol dehydrogenase activity in Saccharomyces cerevisiae strain SM1058 using pCL196 plasmid Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9SZB3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesol + NAD+ highest affinity for the active site of the FLDH enzyme, FLDH-encoded enzyme does not exhibit appreciable farnesal reductase activity Arabidopsis thaliana (2E,6E)-farnesal + NADH + H+
-
ir
geraniol + NAD+
-
Arabidopsis thaliana geranial + NADH + H+
-
?
geranylgeraniol + NAD+
-
Arabidopsis thaliana ? + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
farnesol dehydrogenase
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NAD+ no oxidation observed in the presence of NADP+ Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana FLDH expression is repressed by exogenous abscisic acid and FLDH expression negatively regulates ABA signaling down
Arabidopsis thaliana expression is increased in mutants with T-DNA insertions in the FLDH 5' flanking region indicating that both T-DNA insertions disrupt a cis-acting negative regulatory element in the FLDH promoter up

General Information

General Information Comment Organism
physiological function results suggest that FLDH is a negative regulator of ABA signaling Arabidopsis thaliana