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Literature summary for 1.1.1.35 extracted from

  • van Hove, E.C.; Hansen, T.; Dekker, J.M.; Reiling, E.; Nijpels, G.; Jorgensen, T.; Borch-Johnsen, K.; Hamid, Y.H.; Heine, R.J.; Pedersen, O.; Maassen, J.A.; t Hart, L.M.
    The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study (2006), Diabetes, 55, 3193-3196.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene HADHSC, located on chromosome 4q22-26 Homo sapiens

Protein Variants

Protein Variants Comment Organism
D279E naturally occuring polymorphism probably involved in development of type 2 diabetes Homo sapiens
H152Q naturally occuring polymorphism probably involved in development of type 2 diabetes Homo sapiens
P86L naturally occuring polymorphism probably involved in development of type 2 diabetes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in the penultimate step in mitochondrial fatty acid oxidation and in development of type 2 diabetes ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene HADHSC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the penultimate step in mitochondrial fatty acid oxidation and in development of type 2 diabetes Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
SCHAD
-
Homo sapiens
short-chain L-3-hydroxyacyl-CoA dehydrogenase
-
Homo sapiens