Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluvastatin | - |
Homo sapiens | |
lovastatin | - |
Homo sapiens | |
mevastatin | - |
Homo sapiens | |
additional information | screening of eight-membered medium ring lactams and related tricyclic compounds, either seven-membered lactams, thiolactams or amines, for inhibitory potency, overview. The compounds are inhibitory also in the presence of increasing concentrations of NADPH, and are not affected by increasing concentrations of HMG-CoA. Medium ring lactams and existing statins may have different mechanisms of enzyme interaction and inhibition, molecular docking studies and comparisons using the HMG-CoA reductase statin-binding receptor model, overview. The ligands may occupy a narrow channel housing the pyridinium moiety on NADP+ | Homo sapiens | |
pravastatin | inhibitory in the presence of increasing concentrations of NADPH, but increasing concentrations of HMG-CoA block the HMG-CoA reductase-inhibiting activity | Homo sapiens | |
simvastatin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Homo sapiens | - |
mevalonate + CoA + 2 NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04035 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Homo sapiens | mevalonate + CoA + 2 NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase | - |
Homo sapiens |
HMG-CoA reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | HMG-CoA reductase is the rate-limiting enzyme of cholesterol biosynthesis | Homo sapiens |