Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | leaf tissue of Artemisia annua transgenic lines possess significantly higher HMGR activity compared with wild-type controls, and this activity is associated exclusively with microsomal membranes and with higher artemisinin content (increase of up to 22.5% artemisin in content compared with wild-type control Artemisia annua plants) | Catharanthus roseus |
Application | Comment | Organism |
---|---|---|
drug development | overexpression of HMGR appears promising for obtaining a constant high production of artemisinin, an effective drug against malaria for which no resistant strains of Plasmodium falciparum have been reported | Catharanthus roseus |
Cloned (Comment) | Organism |
---|---|
overexpression of the HMGR gene in transgenic Artemisia annua plants using Agrobacterium-mediated gene transfer technology | Catharanthus roseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + NADPH | Catharanthus roseus | - |
mevalonate + CoA + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Catharanthus roseus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Catharanthus roseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Catharanthus roseus | mevalonate + CoA + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HMG-CoA reductase | - |
Catharanthus roseus |
HMGR | - |
Catharanthus roseus |