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Literature summary for 1.1.1.34 extracted from

  • Feingold, K.R.; Moser, A.H.
    The effect of substrates and competitive inhibitors on the phosphatase dependent activation of hepatic hydroxymethylglutaryl CoA reductase (1986), Arch. Biochem. Biophys., 249, 46-51.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
adenosine-2'-monophospho-5'-diphosphoribose competitive inhibitor for NADPH binding site Rattus norvegicus
Compactin competitive inhibitor for HMG-CoA binding site Rattus norvegicus
lovastatin competitive inhibitor for HMG-CoA binding site Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Rattus norvegicus
-
(R)-mevalonate + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activity is regulated by phosphorylation and dephosphorylation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH
-
Rattus norvegicus (R)-mevalonate + CoA + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus