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Literature summary for 1.1.1.331 extracted from

  • Palaniyandi, K.; Jun, W.
    Low temperature enhanced the podophyllotoxin accumulation vis-a-vis its biosynthetic pathway gene(s) expression in Dysosma versipellis (Hance) M. Cheng - a pharmaceutically important medicinal plant (2020), Process Biochem., 95, 197-203 .
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Cloned(Commentary)

Cloned (Comment) Organism
recombinant overexpression of endogenous enzymes secoisolariciresinol dehydrogenase (SDH) and pinoresinollariciresinol reductase (PLR) in Dysosma versipellis, quantitative RT-PCR expression analysis Dysosma versipellis

Protein Variants

Protein Variants Comment Organism
additional information podophyllotoxin biosynthesis pathway genes expression at low temperature. The low temperature enhances the podophyllotoxin accumulation in Dysosma versipellis Dysosma versipellis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+ Dysosma versipellis
-
 (-)-matairesinol + 2 NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Dysosma versipellis B2LSD3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
rhizome
-
 Dysosma versipellis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+
-
 Dysosma versipellis (-)-matairesinol + 2 NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
SDH
-
 Dysosma versipellis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Dysosma versipellis

Expression

Organism Comment Expression
Dysosma versipellis mRNA expression analysis of podophyllotoxin pathway genes secoisolariciresinol dehydrogenase and pinoresionol lariciresinol reductase shows that the expression levels are upregulated by low temperature. In addition, plants grown at low temperature of 4-6°C show markedly increased podophyllotoxin accumulation compared to 3.49fold in rhizome of Dysosma versipellis than the greenhouse temperature of 25-30°C up

General Information

General Information Comment Organism
metabolism the enzyme catalyzes a step in the podophyllotoxin biosynthesis pathway Dysosma versipellis