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Literature summary for 1.1.1.331 extracted from

  • Moinuddin, S.G.; Youn, B.; Bedgar, D.L.; Costa, M.A.; Helms, G.L.; Kang, C.; Davin, L.B.; Lewis, N.G.
    Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum (2006), Org. Biomol. Chem., 4, 808-816.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K171A mutation in conserved catalytic triad, complete loss of activity Podophyllum peltatum
S153A mutation in conserved catalytic triad, severe reduction of activity Podophyllum peltatum
Y167A mutation in conserved catalytic triad, complete loss of activity Podophyllum peltatum

Organism

Organism UniProt Comment Textmining
Podophyllum peltatum Q94KL8
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-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3500
-
wild-type, pH 8.8, 22°C Podophyllum peltatum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+ NAD+ binds first followed by the substrate (-)-secoisolariciresinol. For hydride transfer, the incoming hydride abstracted from the substrate takes up the pro-S position in the NADH formed Podophyllum peltatum (-)-matairesinol + 2 NADH + 2 H+
-
?

Synonyms

Synonyms Comment Organism
SDH
-
Podophyllum peltatum