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Literature summary for 1.1.1.31 extracted from

  • Hawes, J.W.; Harper, E.T.; Crabb, D.W.; Harris, R.A.
    Structural and mechanistic aspects of a new family of dehydrogenases, the beta-hydroxyacid dehydrogenases (1996), Adv. Exp. Med. Biol., 414, 395-402.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D33R higher affinity to cofactor NADP+ than to natural cofactor NAD+ Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
NAD+ wild type Rattus norvegicus
0.056
-
L-3-hydroxyisobutyrate wild type, NAD as cofactor Rattus norvegicus
0.104
-
L-3-hydroxyisobutyrate wild type, NADP as cofactor Rattus norvegicus
0.11
-
L-3-hydroxyisobutyrate mutant D33R, NADP as cofactor Rattus norvegicus
0.112
-
L-3-hydroxyisobutyrate mutant D33R, NAD as cofactor Rattus norvegicus
0.24
-
NADP+ mutant D33R Rattus norvegicus
0.24
-
NADP+ mutant enzyme D33R, pH and temperature not specified in the publication Rattus norvegicus
0.96
-
NADP+ wild type Rattus norvegicus
0.96
-
NADP+ wild type enzyme, pH and temperature not specified in the publication Rattus norvegicus
1.24
-
NAD+ mutant D33R Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-3-hydroxyisobutyrate + NAD+ Rattus norvegicus
-
L-2-methyl-3-oxopropionate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-beta-hydroxyisobutyrate + NADP+
-
Rattus norvegicus 2-methyl-3-oxopropanoate + NADPH + H+
-
r
L-3-hydroxyisobutyrate + NAD+
-
Rattus norvegicus L-2-methyl-3-oxopropionate + NADH
-
?