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Literature summary for 1.1.1.300 extracted from

  • Wang, H.; Cui, X.; Gu, Q.; Chen, Y.; Zhou, J.; Kuang, Y.; Wang, Z.; Xu, X.
    Retinol dehydrogenase 13 protects the mouse retina from acute light damage (2012), Mol. Vis., 18, 1021-1030.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of Rdh13 knockout mice. No obvious difference in phenotype or function between Rdh13 knockout and wild-type mice. But in Rdh13-/- mice subjected to intense light exposure, the photoreceptor outer-plus-inner-segment and outer nuclear layer are dramatically shorter, and the amplitudes of a- and b-waves under scotopic conditions are significantly attenuated. Increased expression levels of CytC, CytC-responsive apoptosis proteinase activating factor-1 and caspases 3, and other mitochondria apoptosis-related genes, e.g. nuclear factor-kappa B P65 and B-cell lymphoma 2-associated X protein, are observed in Rdh13-/- mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus C57BL/6 x 129/Sv
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
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Mus musculus
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retina
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Mus musculus
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Synonyms

Synonyms Comment Organism
RDH13
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Mus musculus
retinol dehydrogenase 13
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Mus musculus

General Information

General Information Comment Organism
malfunction generation of Rdh13 knockout mice. No obvious difference in phenotype or function between Rdh13 knockout and wild-type mice. But in Rdh13-/- mice subjected to intense light exposure, the photoreceptor outer-plus-inner-segment and outer nuclear layer are dramatically shorter, and the amplitudes of a- and b-waves under scotopic conditions are significantly attenuated. Increased expression levels of CytC, CytC-responsive apoptosis proteinase activating factor-1 and caspases 3, and other mitochondria apoptosis-related genes, e.g. nuclear factor-kappa B P65 and B-cell lymphoma 2-associated X protein, are observed in Rdh13-/- mice Mus musculus