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Literature summary for 1.1.1.300 extracted from
- Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster (2009), Biochim. Biophys. Acta, 1790, 1266-1273.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Sf9 cells | Drosophila melanogaster |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | CG2070-expessing microsomes do not show saturation with up to 0.008 mM all-trans-3-hydroxyretinaldehyde | Drosophila melanogaster | |
| 0.00027 | - |
all-trans-retinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster |  |
| 0.0004 | - |
all-trans-retinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster | |
| 0.0006 | - |
all-trans-retinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster | |
| 0.0007 | - |
all-trans-retinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster | |
| 0.0032 | - |
all-trans-3-hydroxyretinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster | |
| 0.0041 | - |
all-trans-3-hydroxyretinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster | |
| 0.0044 | - |
all-trans-3-hydroxyretinal | Km-value is determined for microsomal preparations expressing recombinant Drosophila proteins | Drosophila melanogaster | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | associated with microsomal membranes | Drosophila melanogaster | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q7JUS1 | - |
- |
| Drosophila melanogaster | Q7JYX2 | - |
- |
| Drosophila melanogaster | Q8MZG9 | - |
- |
| Drosophila melanogaster | Q9W404 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans retinal + NADH + H+ | prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | all-trans-retinol + NAD+ | - |
r | |
| all-trans retinal + NADPH + H+ | prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | all-trans-retinol + NADP+ | - |
r | |
| all-trans-3-hydroxyretinal + NADH + H+ | catalytic efficiency towards all-trans-3-hydroxyretinal is lower than that towards all-trans retinal, prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | all-trans-3-hydroxyretinol + NAD+ | - |
? | |
| all-trans-3-hydroxyretinal + NADPH + H+ | catalytic efficiency towards all-trans-3-hydroxyretinal is lower than that towards all-trans retinal, prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | all-trans-3-hydroxyretinol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CG2065 | - |
Drosophila melanogaster |
| CG2070 | - |
Drosophila melanogaster |
| CG30491 | - |
Drosophila melanogaster |
| CG3842 | - |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | |
| NADH | prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | |
| NADP+ | prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | |
| NADPH | prefers NADP+ and NADPH as cofactors | Drosophila melanogaster | |
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