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Literature summary for 1.1.1.30 extracted from

  • Dutra, J.C.; Dutra-Filho, C.S.; Cardozo, S.E.C.; Wannmacher, C.M.D.; Sarkis, J.J.F.; Wajner, M.
    Inhibition of succinate dehydrogenase and beta-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats (1993), J. Inherit. Metab. Dis., 16, 147-153.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
methylmalonate brain 3-hydroxybutyrate dehydrogenase, 0.5 mM 69% inhibition, 0.75 mM 83%, 1 mM 87%, 1.5 mM 3-hydroxybutyrate, liver 3-hydroxybutyrate dehydrogenase, 0.1 mM 37% inhibition, 0.25 mM 41%, 0.5 mM 45%, 1 mM 3-hydroxybutyrate, competitive inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Rattus norvegicus
-
acetoacetate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.36
-
liver 3-hydroxybutyrate dehydrogenase, mitochondrial extracts Rattus norvegicus
1.26
-
brain 3-hydroxybutyrate dehydrogenase, mitochondrial extracts Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
Rattus norvegicus acetoacetate + NADH
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus