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Literature summary for 1.1.1.3 extracted from

  • Cavari, B.Z.; Grossowicz, N.
    Properties of homoserine dehydrogenase in a thermophilic bacterium (1973), Biochim. Biophys. Acta, 302, 183-190.
    View publication on PubMed
Search for more literature for 1.1.1.3

Inhibitors

Inhibitors Comment Organism Structure
D-threonine slight Thermophilic bacterium
DL-allo-threonine
-
 Thermophilic bacterium
L-cysteine slight Thermophilic bacterium
L-threonine
-
 Thermophilic bacterium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.17 0.18 NADP+
-
 Thermophilic bacterium

Metals/Ions

Metals/Ions Comment Organism Structure
K+ required Thermophilic bacterium
Li+ can partially replace K+ Thermophilic bacterium
Na+ can partially replace K+ Thermophilic bacterium
NH4+ can partially replace K+ Thermophilic bacterium
Rb+ can partially replace K+ Thermophilic bacterium

Organism

Organism UniProt Comment Textmining
Thermophilic bacterium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Thermophilic bacterium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + NAD(P)H
-
 Thermophilic bacterium L-homoserine + NAD(P)+
-
 r
L-homoserine + NAD(P)+
-
 Thermophilic bacterium L-aspartate 4-semialdehyde + NAD(P)H
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
-
 Thermophilic bacterium

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 70 no activity at 80°C Thermophilic bacterium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.8
-
-
 Thermophilic bacterium

pH Range

pH Minimum pH Maximum Comment Organism
8 10
-
 Thermophilic bacterium

Cofactor

Cofactor Comment Organism Structure
NAD+ low activity Thermophilic bacterium
NADP+ preferred Thermophilic bacterium