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Literature summary for 1.1.1.284 extracted from

  • Que, L.G.; Yang, Z.; Stamler, J.S.; Lugogo, N.L.; Kraft, M.
    S-nitrosoglutathione reductase: an important regulator in human asthma (2009), Am. J. Respir. Crit. Care Med., 180, 226-231.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.284

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-nitrosoglutathione + NADH + H+
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GSNOR
-
 Homo sapiens
S-nitrosoglutathione reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens S-nitrosothiol content is decreased in asthmatic bronchoalveolar lavage compared with control bronchoalveolar lavage and correlates inversely with GSNOR expression in bronchoalveolar lavage cell lysates. GSNOR activity in bronchoalveolar lavage samples is significantly increased by 2fold in subjects with asthma compared with control subjects and correlates inversely with the provocative concentration of methacholine causing a 20% decrease in FEV(1) up

General Information

General Information Comment Organism
physiological function GSNOR is an important regulator of airway S-nitrosothiol content and airways hyperresponsiveness in human asthma Homo sapiens