Activating Compound | Comment | Organism | Structure |
---|---|---|---|
formaldehyde | in the presence of NAD+ and initial absence of NADH, ADH3-mediated S-nitrosoglutathione reduction is triggered by the presence of formaldehyde | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00012 | - |
S-hydroxymethylglutathione | in 0.1 M potassium phosphate (pH 7.5), at 25°C | Homo sapiens | |
0.0111 | - |
S-nitrosoglutathione | in 0.1 M potassium phosphate (pH 7.5), at 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Blue-Sepharose 6 column chromatography and Superdex 200 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formaldehyde + glutathione + NAD+ | - |
Homo sapiens | S-formylglutathione + NADH + H+ | - |
r | |
S-hydroxymethylglutathione + NAD+ | - |
Homo sapiens | S-formylglutathione + NADH + H+ | - |
r | |
S-nitrosoglutathione + NADH + H+ | - |
Homo sapiens | S-amino-L-glutathione + NAD+ + ? | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ADH3 | - |
Homo sapiens |
alcohol dehydrogenase 3 | exhibits dual function as S-nitrosoglutathione reductase and glutathione-dependent formaldehyde dehydrogenase | Homo sapiens |
GSNO reductase | - |
Homo sapiens |
GSNOR | - |
Homo sapiens |
S-nitrosoglutathione reductase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.5 | - |
S-hydroxymethylglutathione | in 0.1 M potassium phosphate (pH 7.5), at 25°C | Homo sapiens | |
20 | - |
S-nitrosoglutathione | in 0.1 M potassium phosphate (pH 7.5), at 25°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |