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Literature summary for 1.1.1.284 extracted from

  • Kato, N.; Sahm, H.; Wagner, F.
    Steady-state kinetics of formaldehyde dehydrogenase and formate dehydrogenase from a methanol-utilizing yeast, Candida boidinii (1979), Biochim. Biophys. Acta, 566, 12-20.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione [Candida] boidinii
AMP competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione [Candida] boidinii
ATP competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione [Candida] boidinii
NADH
-
[Candida] boidinii
S-formylglutathione
-
[Candida] boidinii
S-hydroxymethylglutathione
-
[Candida] boidinii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formaldehyde + glutathione + NAD+ [Candida] boidinii key enzyme of the dissimilatory pathway of the methanol metabolism S-formylglutathione + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
[Candida] boidinii
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ ordered bi-bi mechanism [Candida] boidinii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formaldehyde + glutathione + NAD+ the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione [Candida] boidinii S-formylglutathione + NADH + H+
-
r
formaldehyde + glutathione + NAD+ key enzyme of the dissimilatory pathway of the methanol metabolism [Candida] boidinii S-formylglutathione + NADH + H+
-
?
S-formylglutathione + NADH
-
[Candida] boidinii formaldehyde + glutathione + NAD+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
[Candida] boidinii
NADH
-
[Candida] boidinii