Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP-ribose | competitive with respect to beta-NAD+ and non-competitive with glutathione | Homo sapiens | |
Alpha-NAD+ | competitive with respect to beta-NAD+ and non-competitive with glutathione | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0048 | - |
beta-NAD+ | - |
Homo sapiens | |
0.0301 | - |
thio-NAD+ | - |
Homo sapiens | |
0.0352 | - |
nicotinamide-hypoxanthine dinucleotide | - |
Homo sapiens | |
0.0509 | - |
3-acetylpyridine-adenine dinucleotide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ | random sequential mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formaldehyde + glutathione + 3-acetylpyridine-adenine dinucleotide | - |
Homo sapiens | S-formylglutathione + ? | - |
? | |
formaldehyde + glutathione + NAD+ | - |
Homo sapiens | S-formylglutathione + NADH + H+ | - |
? | |
formaldehyde + glutathione + nicotinamide-hypoxanthine dinucleotide | - |
Homo sapiens | S-formylglutathione + ? | - |
? | |
formaldehyde + glutathione + thio-NAD+ | - |
Homo sapiens | S-formylglutathione + thio-NADH | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine adenine dinucleotide | can substitute for beta-NAD+ | Homo sapiens | |
NAD+ | - |
Homo sapiens | |
nicotinamide hypoxanthine dinucleotide | can substitute for beta-NAD+ | Homo sapiens | |
thio-NAD+ | can substitute for beta-NAD+ | Homo sapiens |