Literature summary for 1.1.1.28 extracted from

Xu, T.T.; Bai, Z.Z.; Wang, L.J.; He, B.F.
Breeding of D(-)-lactic acid high producing strain by low-energy ion implantation and preliminary analysis of related metabolism (2008), Appl. Biochem. Biotechnol., 160, 314-321.

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Protein Variants

Protein Variants	Comment	Organism
additional information	random mutagensis, and screening for gain-of-function mutants, mutant Y2-8 shows improved D(-)-lactate synthesis, which is 2fold increased compared to the wild-type strain DX12	Sporolactobacillus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyruvate + NADH	Sporolactobacillus sp.	-	(R)-lactate + NAD+	-	r
pyruvate + NADH	Sporolactobacillus sp. DX12	-	(R)-lactate + NAD+	-	r

Organism

Organism	UniProt	Comment	Textmining
Sporolactobacillus sp.	-	isolated from soil	-
Sporolactobacillus sp. DX12	-	isolated from soil	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + NADH	-	Sporolactobacillus sp.	(R)-lactate + NAD+	-	r
pyruvate + NADH	-	Sporolactobacillus sp. DX12	(R)-lactate + NAD+	-	r
pyruvate + NADH + H+	-	Sporolactobacillus sp.	(R)-lactate + NAD+	-	r
pyruvate + NADH + H+	-	Sporolactobacillus sp. DX12	(R)-lactate + NAD+	-	r

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Release 2023.1 (January 2023)