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Literature summary for 1.1.1.278 extracted from
- Progesterone metabolism in the gastric mucosa microsomes of guinea pig (1989), J. Steroid Biochem., 32, 835-840.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5alpha-pregnan-3,20-dione + NADPH | Cavia porcellus | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r |  |
| 5alpha-pregnan-3,20-dione + NADPH | Rattus norvegicus | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
| 5alpha-pregnan-3,20-dione + NADPH | Oryctolagus cuniculus | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | - |
Cavia porcellus | - |
| gastric mucosa | - |
Cavia porcellus | - |
| gastric mucosa | - |
Rattus norvegicus | - |
| gastric mucosa | - |
Oryctolagus cuniculus | - |
| small intestine | - |
Cavia porcellus | - |
| stomach | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
activity is determined as progesterone-metabolizing activity including steroid 5alpha-reductase and 3beta-hydroxysteroid dehydrogenase activity | Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5alpha-pregnan-3,20-dione + NAD(P)H | - |
Cavia porcellus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
| 5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
| 5alpha-pregnan-3,20-dione + NAD(P)H | - |
Oryctolagus cuniculus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
| 5alpha-pregnan-3,20-dione + NADPH | - |
Cavia porcellus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
| 5alpha-pregnan-3,20-dione + NADPH | - |
Rattus norvegicus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
| 5alpha-pregnan-3,20-dione + NADPH | - |
Oryctolagus cuniculus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3beta-hydroxy steroid dehydrogenase | - |
Cavia porcellus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cavia porcellus |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Cavia porcellus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Cavia porcellus | |
| NADP+ | - |
Rattus norvegicus | |
| NADPH | - |
Cavia porcellus | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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