Literature summary for 1.1.1.271 extracted from

Malaga, W.; Constant, P.; Euphrasie, D.; Cataldi, A.; Daffe, M.; Reyrat, J.M.; Guilhot, C.
Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex (2008), J. Biol. Chem., 283, 15177-15184.

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Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, enzyme expression in Mycobacterium bovis leads to restoration of wild-type phenotype producing triglycosylated phenolic glycolipids instead of monoglycosylated as in the mutant, mass spectrometric lipid spectrum analysis, overview	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GDP-4-dehydro-6-deoxy-D-mannose + NADPH	Mycobacterium tuberculosis	the enzyme is required for the formation of activated L-fucose	GDP-L-fucose + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
no activity in Mycobacterium bovis	-	due to a natural mutation deleting the gene encoding the enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-4-dehydro-6-deoxy-D-mannose + NADPH	-	Mycobacterium tuberculosis	GDP-L-fucose + NADP+	-	r
GDP-4-dehydro-6-deoxy-D-mannose + NADPH	the enzyme is required for the formation of activated L-fucose	Mycobacterium tuberculosis	GDP-L-fucose + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase/reductase	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)