Cloned (Comment) | Organism |
---|---|
expression of HSD17B7 and truncated HSD17B7 (shortened by 127 amino acids at the C terminus) as glutathione-S-transferase fusion protein in Escherichia coli. Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium | Homo sapiens |
expression of HSD17B7 as a glutathione-S-transferase fusion protein in Escherichia coli. Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
DELTA214-341 | inactive mutant enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | HSD17B7 participates in postsqualene cholesterol biosynthesis | ? | - |
? | |
additional information | Homo sapiens | HSD17B7 participates in postsqualene cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | high expression levels in the ganglion of the trigeminal nerve and the dorsal root ganglia | Mus musculus | - |
ganglion | of the trigeminal nerve, dorsal root ganglia, cranial ganglia | Mus musculus | - |
additional information | specifically expressed in tissues that are involved in the pathogenesis of congenital cholesterol-deficiency disorders | Mus musculus | - |
neural tube | - |
Mus musculus | - |
tail bud | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | HSD17B7 participates in postsqualene cholesterol biosynthesis | Mus musculus | ? | - |
? | |
additional information | HSD17B7 participates in postsqualene cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism | Homo sapiens | ? | - |
? | |
zymosterone + NADPH | - |
Mus musculus | zymosterol + NADP+ | - |
? | |
zymosterone + NADPH | - |
Homo sapiens | zymosterol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HSD17B7 | - |
Mus musculus |
HSD17B7 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens |