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Literature summary for 1.1.1.270 extracted from

  • Wieland, S.J.; Fox, T.O.
    A DNA-binding of mouse kidney 3-ketosteroid reductase: comparison with androgen receptors (1981), Steroids, 37, 527-538.
    View publication on PubMed
Search for more literature for 1.1.1.270

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme might form complexes with other proteins, including possibly DNA-binding proteins, under low ionic strength conditions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hypothalamus
-
 Mus musculus
-
kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxy-5alpha-androstan-3-one + NADPH 5alpha-dihydrotestosterone Mus musculus 5alpha-androstane-3beta,17beta-diol + NADP+ androstanediol ?
17beta-hydroxy-5alpha-androstan-3-one + NADPH 5alpha-dihydrotestosterone Mus musculus 5alpha-androstane-3beta,17beta-diol + NADP+ 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ?
17beta-hydroxy-5alpha-androstan-3-one + NADPH DHT Mus musculus 5alpha-androstane-3beta,17beta-diol + NADP+ androstanediol ?
17beta-hydroxy-5alpha-androstan-3-one + NADPH DHT Mus musculus 5alpha-androstane-3beta,17beta-diol + NADP+ 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ?
17beta-hydroxy-5alpha-androstan-3-one + NADPH dihydrotestosterone Mus musculus 5alpha-androstane-3beta,17beta-diol + NADP+ androstanediol ?
17beta-hydroxy-5alpha-androstan-3-one + NADPH dihydrotestosterone Mus musculus 5alpha-androstane-3beta,17beta-diol + NADP+ 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ?
additional information enzyme might form complexes with other proteins, including possibly DNA-binding proteins, under low ionic strength conditions Mus musculus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Mus musculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
-
 Mus musculus
25
-
 2 h at 25°C: 84% of activity remained, 8 h at 25°C: 74-76% of activity remained Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus