Organism | UniProt | Comment | Textmining |
---|---|---|---|
synthetic construct | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH | - |
synthetic construct | ? + NADP+ | - |
? | |
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
synthetic construct | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
additional information | a retroaldol/aldol mechanism for the DXR catalyzed rearrangement of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate. DXR first cleaves the C3-C4 bond of 1-deoxy-D-xylulose 5-phosphate in a retroaldol manner to generate a three-carbon and a two-carbon phosphate bimolecular intermediate. These two species are then reunited by an aldol reaction to form a new C-C bond, yielding the same aldehyde intermediate methylerythrose phosphate. Subsequent reduction of methylerythrose phosphate by NADPH affords 2-C-methyl-D-erythritol 4-phosphate | synthetic construct | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DXP reductoisomerase | - |
synthetic construct |
DXR | - |
synthetic construct |
MEP synthase | - |
synthetic construct |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
13.2 | - |
1-deoxy-D-xylulose 5-phosphate | - |
synthetic construct | |
13.7 | - |
1-deoxy-D-xylulose 5-phosphate | - |
synthetic construct | |
16.1 | - |
1-deoxy-D-xylulose 5-phosphate | - |
synthetic construct |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | synthetic construct |