Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
docking models for inhibitor (3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid based on crystal structure in complex with fosmidomycin. Formation of a hydrogen bond between an appropriately placed carbonyl group in the acyl residue and the main-chain NH of M214 located in the flexible catalytic loop of the enzyme | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3-(hydroxy[(pentafluorophenyl)carbonyl]amino)propyl)phosphonic acid | - |
Escherichia coli | |
(3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid | - |
Escherichia coli | |
(3-[hydroxy(6-phenylhexanoyl)amino]propyl)phosphonic acid | - |
Escherichia coli | |
(3-[hydroxy(hexadecanoyl)amino]propyl)phosphonic acid | - |
Escherichia coli | |
fosmidomycin | - |
Escherichia coli | |
FR900098 | N-acetyl homologue of fosmidomycin | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P45568 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000035 | - |
pH 7.5, 30°C | Escherichia coli | fosmidomycin | |
0.000035 | - |
pH 7.5, 30°C | Escherichia coli | FR900098 | |
0.0013 | - |
pH 7.5, 30°C | Escherichia coli | (3-(hydroxy[(pentafluorophenyl)carbonyl]amino)propyl)phosphonic acid | |
0.0051 | - |
pH 7.5, 30°C | Escherichia coli | (3-[hydroxy(6-phenylhexanoyl)amino]propyl)phosphonic acid | |
0.0054 | - |
pH 7.5, 30°C | Escherichia coli | (3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid | |
0.0056 | - |
pH 7.5, 30°C | Escherichia coli | (3-[hydroxy(hexadecanoyl)amino]propyl)phosphonic acid |