Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.267 extracted from

  • Ortmann, R.; Wiesner, J.; Silber, K.; Klebe, G.; Jomaa, H.; Schlitzer, M.
    Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues (2007), Arch. Pharm., 340, 483-490.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
docking models for inhibitor (3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid based on crystal structure in complex with fosmidomycin. Formation of a hydrogen bond between an appropriately placed carbonyl group in the acyl residue and the main-chain NH of M214 located in the flexible catalytic loop of the enzyme Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(3-(hydroxy[(pentafluorophenyl)carbonyl]amino)propyl)phosphonic acid
-
Escherichia coli
(3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid
-
Escherichia coli
(3-[hydroxy(6-phenylhexanoyl)amino]propyl)phosphonic acid
-
Escherichia coli
(3-[hydroxy(hexadecanoyl)amino]propyl)phosphonic acid
-
Escherichia coli
fosmidomycin
-
Escherichia coli
FR900098 N-acetyl homologue of fosmidomycin Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P45568
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000035
-
pH 7.5, 30°C Escherichia coli fosmidomycin
0.000035
-
pH 7.5, 30°C Escherichia coli FR900098
0.0013
-
pH 7.5, 30°C Escherichia coli (3-(hydroxy[(pentafluorophenyl)carbonyl]amino)propyl)phosphonic acid
0.0051
-
pH 7.5, 30°C Escherichia coli (3-[hydroxy(6-phenylhexanoyl)amino]propyl)phosphonic acid
0.0054
-
pH 7.5, 30°C Escherichia coli (3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid
0.0056
-
pH 7.5, 30°C Escherichia coli (3-[hydroxy(hexadecanoyl)amino]propyl)phosphonic acid