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Literature summary for 1.1.1.252 extracted from

  • Wheeler, M.H.; Greenblatt, G.A.
    The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease (1988), Exp. Mycol., 12, 151-160.
No PubMed abstract available
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Application

Application Comment Organism
agriculture the effect of melanin inhibitors on the enzyme activity can be used to predict their effect in preventing rice blast disease Pyricularia oryzae

Inhibitors

Inhibitors Comment Organism Structure
2,3,4,5,6-Pentachlorobenzyl alcohol
-
 Pyricularia oryzae
Chlobenthiazone
-
 Pyricularia oryzae
Fthalide
-
 Pyricularia oryzae
additional information the effect of melanin inhibitors on the enzyme activity can be used to predict their effect in preventing rice blast disease Pyricularia oryzae
N-Methyl-2-quinolone weak Pyricularia oryzae
Pyroquilon
-
 Pyricularia oryzae
s-Triazolo[4,3-a]-quinoline weak Pyricularia oryzae
Tricyclazole
-
 Pyricularia oryzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,3,6,8-Tetrahydroxynaphthalene + NADPH Pyricularia oryzae the enzyme is involved in the pentaketide pathway of melanin and flaviolin and 2-HJ Scytalone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Pyricularia oryzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3,6,8-Tetrahydroxynaphthalene + NADPH
-
 Pyricularia oryzae Scytalone + NADP+
-
 ?
1,3,6,8-Tetrahydroxynaphthalene + NADPH the enzyme is involved in the pentaketide pathway of melanin and flaviolin and 2-HJ Pyricularia oryzae Scytalone + NADP+
-
 ?
1,3,8-trihydroxynaphthalene + NADPH + H+
-
 Pyricularia oryzae vermelone + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Pyricularia oryzae