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Literature summary for 1.1.1.247 extracted from

  • Gollwitzer, J.; Lenz, R.; Hampp, N.; Zenk, M.H.
    The transformation of neopinone to codeinone in morphine biosynthesis proceeds non-enzymatically (1993), Tetrahedron Lett., 34, 5703-5706.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Codeinone + NADPH Papaver somniferum neopinone, which is formed most likely by demethylation of the vinylether of thebaine exists in the plant cell in a thermodynamic equilibrium with codeinone. The presence of the codeinone reductase/NADPH system shifts this equilibrium quantitatively in the direction of codeine, which either accumulates in the latex of the poppy plant or is further demethylated at the 3-OCH3 group yielding morphine Codeine + NADP+
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Organism

Organism UniProt Comment Textmining
Papaver somniferum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Codeinone + NADPH r Papaver somniferum Codeine + NADP+
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Codeinone + NADPH neopinone, which is formed most likely by demethylation of the vinylether of thebaine exists in the plant cell in a thermodynamic equilibrium with codeinone. The presence of the codeinone reductase/NADPH system shifts this equilibrium quantitatively in the direction of codeine, which either accumulates in the latex of the poppy plant or is further demethylated at the 3-OCH3 group yielding morphine Papaver somniferum Codeine + NADP+
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