General Stability | Organism |
---|---|
denatured enzyme does not catalyze the reduction of tropinone with NADPH | Datura inoxia |
very unstable | Datura stramonium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
tropinone + NADPH + H+ | Datura inoxia | - |
pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Datura stramonium | - |
pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Atropa belladonna | - |
pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Hyoscyamus niger | - |
pseudotropine + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Atropa belladonna | - |
- |
- |
Datura inoxia | - |
- |
- |
Datura stramonium | - |
- |
- |
Hyoscyamus niger | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Datura inoxia |
- |
Hyoscyamus niger |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Datura inoxia | - |
root | - |
Datura stramonium | - |
root | - |
Atropa belladonna | - |
root | - |
Hyoscyamus niger | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0145 | - |
- |
Datura inoxia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methyl-4-piperidone + NADPH | - |
Datura stramonium | N-methylpiperidin-4-ol + NADP+ | - |
? | |
N-methyl-4-piperidone + NADPH | more efficient substrate, 230% of activity with tropinone | Hyoscyamus niger | N-methylpiperidin-4-ol + NADP+ | - |
? | |
N-methyltropinone + NADPH | - |
Datura inoxia | N-methyl-3-beta-tropine + NADP+ | - |
ir | |
N-propyl-4-piperidone + NADPH | - |
Datura stramonium | N-propylpiperidin-4-ol + NADP+ | - |
? | |
N-propyl-4-piperidone + NADPH | more efficient substrate, 300% of activity with tropinone | Hyoscyamus niger | N-propylpiperidin-4-ol + NADP+ | - |
? | |
tropine + NADP+ | - |
Datura stramonium | tropinone + NADPH | - |
r | |
tropinone + NADPH + H+ | - |
Datura inoxia | pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Datura stramonium | pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Datura stramonium | pseudotropine + NADP+ | - |
ir | |
tropinone + NADPH + H+ | - |
Atropa belladonna | pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Hyoscyamus niger | pseudotropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | enzymes fails to catalyze the oxidation of tropine to tropinone in presence of NADP+ | Datura inoxia | pseudotropine + NADP+ | - |
ir | |
tropinone + NADPH + H+ | - |
Datura stramonium | tropine + NADP+ | only tropine formed by the reduction of tropinone, no evidence for the formation of psi-tropine | r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
tropine oxidation | Datura stramonium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Hyoscyamus niger |
6.4 | - |
- |
Datura inoxia |
6.8 | - |
tropinone reduction | Datura stramonium |
9.5 | - |
tropine oxidation | Datura stramonium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | less effective by a factor of 3.7 than NADPH | Datura stramonium | |
NADH | preference for NADPH, velocity 5.4% of the velocity found with NADPH | Hyoscyamus niger | |
NADH | 70-80% reduction in psi tropine forming reductase activity when NADH is substituted for NADPH | Datura inoxia | |
NADP+ | oxidation does not occur when NAD+ is substituted for NADP+ | Datura stramonium | |
NADPH | - |
Datura stramonium | |
NADPH | - |
Hyoscyamus niger |