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Literature summary for 1.1.1.225 extracted from
- Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man (1986), J. Toxicol. Environ. Health, 17, 375-384.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ethacrynic acid | - |
Homo sapiens |  |
| Ethacrynic acid | - |
Meriones unguiculatus | |
| indomethacin | - |
Homo sapiens | |
| indomethacin | - |
Meriones unguiculatus | |
| additional information | not inhibited by phenobarbital | Homo sapiens | |
| additional information | not inhibited by phenobarbital | Meriones unguiculatus | |
| p-chloromercuribenzoate | - |
Homo sapiens | |
| p-chloromercuribenzoate | strong inhibition | Meriones unguiculatus | |
| quercetin | - |
Homo sapiens | |
| quercetin | weak inhibition | Meriones unguiculatus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0026 | - |
Chlordecone | - |
Meriones unguiculatus | |
| 0.005 | - |
NADPH | - |
Meriones unguiculatus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
| cytoplasm | - |
Meriones unguiculatus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Meriones unguiculatus | - |
- |
- |
| no activity in Cavia porcellus | - |
- |
- |
| no activity in Mesocricetus auratus | - |
- |
- |
| no activity in Mus musculus | - |
- |
- |
| no activity in Rattus norvegicus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Meriones unguiculatus | - |
| heart | - |
Meriones unguiculatus | - |
| intestine | - |
Meriones unguiculatus | - |
| kidney | - |
Meriones unguiculatus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Meriones unguiculatus | - |
| lung | - |
Meriones unguiculatus | - |
| additional information | found in all tissues, highest activity in liver, intestine and kidney | Meriones unguiculatus | - |
| spleen | - |
Meriones unguiculatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH | organochlorine pesticide, trivial names: chlordecone or kepone | Homo sapiens | chlordecone alcohol + NADP+ | - |
? | |
| 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH | organochlorine pesticide, trivial names: chlordecone or kepone | Oryctolagus cuniculus | chlordecone alcohol + NADP+ | - |
? | |
| 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH | organochlorine pesticide, trivial names: chlordecone or kepone | Meriones unguiculatus | chlordecone alcohol + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Meriones unguiculatus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Oryctolagus cuniculus | |
| NADPH | - |
Meriones unguiculatus | |
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