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Literature summary for 1.1.1.22 extracted from
- UDP-glucose dehydrogenase from Capra hircus liver: Purification, partial characterization and evaluation as a coupling enzyme in UDP-galactose 4-epimerase assay (2011), J. Mol. Catal. B, 68, 37-43.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NADH | 0.05 mM, partial inhibition | Capra hircus |  |
| UDP | 0.5 mM, partial inhibition | Capra hircus | |
| UDP-alpha-D-glucuronate | 0.05 mM, partial inhibition | Capra hircus | |
| UDP-galactose | 0.5 mM, partial inhibition | Capra hircus | |
| UDP-xylose | 0.05 mM, partial inhibition | Capra hircus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
UDP-alpha-D-glucose | pH 8.8, 25°C | Capra hircus | |
| 0.132 | - |
NAD+ | pH 8.8, 25°C | Capra hircus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
6 * 50000, SDS-PAGE | Capra hircus |
| 300000 | - |
gel filtration | Capra hircus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Capra hircus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Capra hircus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 342.9 | - |
pH 8.8, 25°C | Capra hircus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrates: UDP-D-galactose, UTP, 5'-UMP and D-galactose | Capra hircus | ? | - |
? | |
| UDP-alpha-D-glucose + 2 NAD+ + H2O | - |
Capra hircus | UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 50000, SDS-PAGE | Capra hircus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 45 | - |
Capra hircus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.4 | - |
- |
Capra hircus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8.8 | - |
80-83% of maximum activity | Capra hircus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.4 | 6.5 | enzyme retains 93-97% of initial activity | Capra hircus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Capra hircus | |
| NADP+ | about 5-12% of the activity with NAD+ | Capra hircus | |
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