Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for treatment of chronic pain in neuropathic diseases, overview | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
x * 33000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha,5alpha-allopregnenolone + NAD(P)+ | Rattus norvegicus | i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP, the enzyme catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone, which stimulates GABAA receptors, sciatic nerves-induced analgesia results in increased enzyme levels in neuropathic rats, overview | 5alpha-dihydroprogesterone + NAD(P)H | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sciatic nerve | lumbar, of naive, sham-operated and neuropathic rats, enzyme expression analysis and cellular distribution in neurons and glial cells, immunohistochemic analysis, overview | Rattus norvegicus | - |
spinal cord | abundant enzyme expression | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha,5alpha-allopregnenolone + NAD(P)+ | i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP, the enzyme catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone, which stimulates GABAA receptors, sciatic nerves-induced analgesia results in increased enzyme levels in neuropathic rats, overview | Rattus norvegicus | 5alpha-dihydroprogesterone + NAD(P)H | - |
r | |
3alpha,5alpha-allopregnenolone + NAD(P)+ | i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP | Rattus norvegicus | 5alpha-dihydroprogesterone + NAD(P)H | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 33000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
3alpha-HSOR | - |
Rattus norvegicus |
3alpha-hydroxysteroid oxido-reductase | - |
Rattus norvegicus |
More | cf. EC 1.1.1.50 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Rattus norvegicus | |
NAD(P)H | - |
Rattus norvegicus |