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Literature summary for 1.1.1.213 extracted from

  • Pawlowski, J.E.; Huizinga, M.; Penning, T.M.
    Cloning and sequencing of the cDNA for rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (1991), J. Biol. Chem., 266, 8820-8825.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
plasmid DNA containing cDNA is transformed in Escherichia coli HB101, cDNA is used for sequencing Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
1 * 34000 SDS-PAGE Rattus norvegicus
37030
-
predicted molecular weight from the cDNA Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+ Rattus norvegicus termination of androgen action 3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
-
?
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+ Rattus norvegicus Sprangue-Dawley termination of androgen action 3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
-
?
additional information Rattus norvegicus involved in biosynthesis of bile acids ?
-
?
additional information Rattus norvegicus Sprangue-Dawley involved in biosynthesis of bile acids ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprangue-Dawley
-
Rattus norvegicus Sprangue-Dawley
-
Sprangue-Dawley
-

Reaction

Reaction Comment Organism Reaction ID
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ bi bi mechanism, pyridine nucleotide binds before substrate Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
additional information indomethacin-sensitive 3alpha-hydroxysteroid dehydrogenase widely distributed in prostate, spleen, heart, testis, small intestine, stomach, lung and brain Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+ termination of androgen action Rattus norvegicus 3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
-
?
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+ termination of androgen action Rattus norvegicus Sprangue-Dawley 3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
-
?
additional information metabolizes androgens and glucocorticoids, function as a dihydrodiol dehydrogenase as well as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase, enzyme catalyzes both oxidation and reduction reaction at physiological pH and is able to reduce aromatic ketones Rattus norvegicus ?
-
?
additional information involved in biosynthesis of bile acids Rattus norvegicus ?
-
?
additional information metabolizes androgens and glucocorticoids, function as a dihydrodiol dehydrogenase as well as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase, enzyme catalyzes both oxidation and reduction reaction at physiological pH and is able to reduce aromatic ketones Rattus norvegicus Sprangue-Dawley ?
-
?
additional information involved in biosynthesis of bile acids Rattus norvegicus Sprangue-Dawley ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 34000 SDS-PAGE Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
additional information dual pyridine nucleotide specificity, cofactor binding-site is located at the NH2 terminus Rattus norvegicus