Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.210 extracted from

  • Chen, Q.; Rosik, L.O.; Nancarrow, C.D.; Sweet, F.
    Fetal lamb 3beta,20alpha-hydroxysteroid oxidoreductase: dual activity at the same active site examined by affinity labeling with 16alpha-(bromo[2-14C]acetoxy)progesterone (1989), Biochemistry, 28, 8856-8863.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic studies Ovis aries

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Ovis aries
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
gel filtration Ovis aries
36000
-
SDS-PAGE Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Ovis aries

Reaction

Reaction Comment Organism Reaction ID
5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+ 3beta and 20alpha substrates share the same active site Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte fetal Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0096
-
20alpha-reductase activity Ovis aries

Storage Stability

Storage Stability Organism
-20°C, purified enzyme, indefinitely stable Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydoxy-5alpha-androstan-3-one + NADPH
-
Ovis aries 5alpha-androstan-3beta,17beta-diol + NADP+
-
?
progesterone + NADPH
-
Ovis aries 20alpha-hydroxy-4-pregnen-3-one + NADP+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 36000, SDS-PAGE Ovis aries

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Ovis aries
NADPH
-
Ovis aries