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Literature summary for 1.1.1.21 extracted from

  • Saito, R.; Suzuki, S.; Sasaki, K.
    Pterin-7-carboxamides as a new class of aldose reductase inhibitors (2016), Bioorg. Med. Chem. Lett., 26, 4870-4874.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid
-
 Homo sapiens
2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
-
 Homo sapiens
2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
-
 Homo sapiens
4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
-
 Homo sapiens
5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
-
 Homo sapiens
6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
-
 Homo sapiens
epalrestat
-
 Homo sapiens
folic acid
-
 Homo sapiens
additional information analysis of pterin-7-carboxamides as aldose reductase inhibitors, evaluation of the inhibitory activity of the compounds Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine
-
 Homo sapiens
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanine 9% inhibition at 10.5 mM Homo sapiens
sorbinil
-
 Homo sapiens
[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-

Synonyms

Synonyms Comment Organism
AKR1B1 gene name, UniProt Homo sapiens
aldose reductase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000665
-
 pH and temperature not specified in the publication Homo sapiens epalrestat
0.00197
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine
0.00402
-
 pH and temperature not specified in the publication Homo sapiens 6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
0.0117
-
 pH and temperature not specified in the publication Homo sapiens 5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
0.0124
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine
0.0175
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine
0.0251
-
 pH and temperature not specified in the publication Homo sapiens 2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
0.0255
-
 pH and temperature not specified in the publication Homo sapiens 4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
0.0265
-
 pH and temperature not specified in the publication Homo sapiens 2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
0.0292
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine
0.0426
-
 pH and temperature not specified in the publication Homo sapiens [(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid
0.046
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
0.0525
-
 pH and temperature not specified in the publication Homo sapiens folic acid
0.0617
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine
0.069
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine
0.0834
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine
0.216
-
 pH and temperature not specified in the publication Homo sapiens N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine