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Literature summary for 1.1.1.21 extracted from

  • Tammali, R.; Saxena, A.; Srivastava, S.K.; Ramana, K.V.
    Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells (2011), J. Biol. Chem., 286, 24089-24100.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
fidarestat
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha and vascular endothelial growth factor by regulating 26 S proteasome-mediated protein degradation in colon cancer cells, molecular mechanism, overview. Inhibition of hypoxia-induced HIF-1 protein accumulation by enzyme inhibition is abolished in the presence of MG132, a potent inhibitor of the 26 S proteasome. Enzyme inhibition also prevents the hypoxia-induced inflammatory molecules such as Cox-2 and PGE2 and expression of extracellular matrix proteins such as MMP2, vimentin, uPAR, and lysyl oxidase 2, overview Homo sapiens
physiological function the enzyme in involved in the hypoxia-induced colon cancer cells growth and invasion, overview Homo sapiens