Cloned (Comment) | Organism |
---|---|
expression of ALR2 in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
purified recombinant ALR2, with the oxidized form of beta-NADPH, pH 5.0, 4°C, X-ray diffraction structure determination and analysis at 1.8 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lidorestat | - |
Homo sapiens | |
additional information | development of series of highly potent and selective [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid aldose reductase inhibitors. The compounds inhibit aldose reductase, but are inactive against aldehyde reductase | Homo sapiens | |
[3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | - |
Homo sapiens | |
[6-ethyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | - |
Homo sapiens | |
[6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | Homo sapiens | aldose reductase, ALR2 | sorbitol + NADP+ | - |
? | |
sorbitol + NAD+ | Homo sapiens | aldehyde reductase, ALR1 | D-fructose + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | aldose reductase, ALR2 | Homo sapiens | sorbitol + NADP+ | - |
? | |
sorbitol + NAD+ | aldehyde reductase, ALR1 | Homo sapiens | D-fructose + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldehyde reductase | - |
Homo sapiens |
aldose reductase | - |
Homo sapiens |
ALR1 | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
ALR2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | lidorestat | |
0.000007 | - |
ALR2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | |
0.000008 | - |
ALR2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | |
0.000012 | - |
ALR2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [6-ethyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | |
0.027 | - |
ALR1, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | lidorestat | |
0.1 | - |
above, ALR1, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | |
0.1 | - |
above, ALR1, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid | |
0.1012 | - |
above, ALR1, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [6-ethyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid |
General Information | Comment | Organism |
---|---|---|
metabolism | aldose reductase, ALR2, and aldehyde reductase, ALR1, catalyse two following steps in the polyol pathway, overview | Homo sapiens |